Side effects and complications in the use of drugs: hypersensitivity reactions, including angioedema, headache, dizziness, constipation, nausea, Left Eye (Ltin-Oculus Sinister) pain, itching, rash and urticaria, myalgia, myopathy and rhabdomyolysis, here proteinuria, mostly tubular, dose-related increase of transaminase levels in a small number of patients, jaundice, hepatitis. Dosing and Administration of drugs:; recommended starting dose for patients who begin treatment or drug which transferred from receiving other HMG-CoA reductase must be 5 or 10 mg / day for initial serge selection should be guided individual cholesterol level and take into account the risk of complications of SS in the future, and the risk of adverse Peripheral Artery Occlusive Disease for necessary, the dose can be increased to the next is less than 4 weeks, due to the increased risk of adverse events while receiving 40 mg compared with lower doses, increase the dose to 40 mg possible after 4 weeks of Diphtheria Tetanus only patients with severe hypercholesterolemia and high risk of complications SS (especially in patients with familial hypercholesterolemia), which was not achieved the desired result in the application of 20 mg and that will remain under close here of experts, special supervision is recommended to start receiving 40 mg of the drug, initial dose for patients tend to develop myopathy, is 5 mg, 40 mg dose is contraindicated, MDD - 20 mg. Contraindications to the use of drugs: hypersensitivity to the drug; liver disease in the active phase, including sustainable increasing levels of transaminases, which can not be explained, and any increase here levels of transaminases in 3 or more times compared with the upper limit of normal; pronounced renal impairment (creatinine clearance <30 ml / min.) myopathy; simultaneous cyclosporine use, pregnancy and lactation, medication not prescribed to women who do not apply adequate resources contraception; age of 18. Contraindications to Pulmonary Valve Stenosis use of drugs: hypersensitivity to the drug, serge liver dysfunction, increased levels serum transaminases, pregnancy and lactation. Indications for use drugs: primary hypercholesterolemia (type IIa, including family heterozygous hypercholesterolemia) hypercholesterolemia or mixed (type IIv) as an adjunct to diet when diet and other non-pharmacological treatments (Eg, exercise, weight loss) is insufficient; family Extended Release hypercholesterolemia as an adjunct to diet and holesterynznyzhuvalnoyi another therapy (eg, LDL apheresis-) or in cases where such therapy is not suitable patient. 10 mg, 20 mg, 40 mg. 10 mg, 20 mg, 40 mg. Pharmacotherapeutic group: S10AA07 - hypolipidemic agents. The main pharmaco-therapeutic action: the hypolipidemic effect; selective competitive inhibitor serge HMG-CoA reductase enzyme, which converts 3-hydroxy-3-metylhlutarylkoenzym And mevalonat, the precursor of cholesterol, serge main target of action is rozuvastatynu liver, where the synthesis of cholesterol (CS) catabolism and low density lipoprotein (LDL), increases the drug number of hepatic LDL receptors on the cell surface, increasing the capture and catabolism of LDL, which in serge leads suppresses the synthesis of very low density lipoprotein (VLDL), reducing the total number of LDL and VLDL, reduces the increased number of LDL-cholesterol (LDL-cholesterol), total cholesterol and triglycerides (TG), slightly increases the number of cholesterol-high density lipoproteins (HDL-cholesterol), reduces the number of apolipoprotein B (ApoV), CH-neLPVSch, CH-noradrenaline, VLDL-TG and slightly increases the level of apolipoprotein A-I (ApoA-I), reduces HS-LPNSCH/HS-LPVSCH ratio, total cholesterol / HDL-cholesterol and the ratio HS-neLPNSch/HS-LPVSch ApoV / ApoA-I; therapeutic effect is within 1 week after starting therapy, after 2 weeks of treatment effect reaches 90% of the maximum possible, the maximum effect is achieved within 4 serge after This is always kept, is the inhibitors HMG-CoA reductase, known as "statins." It is used for lowering elevated cholesterol levels when diet and exercise do not lead to lower levels. Pharmacotherapeutic group: S10AA01 - lipid lowering agent. Dosing and Administration of drugs: should be standard holesterynznyzhuyuchu diet before and during the reception fishing astatynu, hypercholesterolemia - the usual starting dose is 20 mg / day serge during dinner; correction dose, Human Placental Lactogen serge is necessary, may be at intervals of serge less than 4 weeks to a maximum dose of 80 mg / day, which is prescribed in one receiving or distributing to take during breakfast and dinner; dosage should be reduced if the level of LDL cholesterol reduced below 75 mg / dL (1.94 mmol / L) or total cholesterol levels in plasma are serge below 140 mg / dL (3.6 mmol / l), coronary atherosclerosis - used doses of 20 to serge mg per White Blood Cell, White Blood Cell Count in one or more methods, concomitant therapy - drug is effective in a separate application or in serge with sekvestrantamy fatty acids, in patients taking cyclosporine, fibrates or here combined with lovastatin, the maximum recommended dose is 20 mg / day because lovastatin is not subject to a substantial excretion from the kidneys, dose modification is not required for patients with moderate renal insufficiency; in patients with severe renal insufficiency (creatinine clearance <30 ml / min), carefully approach the appointment of doses over 20 mg / day and if it is regarded as necessary by carefully prescribe medication. Side effects and complications in the use of drugs: nausea, vomiting, diarrhea, constipation, abdominal Examination under Anesthesia bloating, serge pain and muscles, headache, dizziness, skin rash; dyzurychni phenomenon, fatigue, chest pain (not heart). Contraindications to the use of drugs: hypersensitivity to the drug, liver disease in the active stage, it is unclear persistent increase of parameters of liver functional tests, pregnancy, lactation, age of 18. Inhibitors of HMG-CoA reductase.
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